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N-Acetylcysteine Ethyl Ester (NACET): A Novel Lipophilic Cell-Permeable Cysteine Derivative with an Unusual Pharmacokinetic Feature and Remarkable Antioxidant Potential

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However, in the context of persistent exposure and chronic inflammation in COPD, reduced mitochondrial biogenesis, imbalance in fusion/fission, and insufficient or excessive activation of mitophagy transform mitochondrial injury from a transient stress into a chronic cumulative process (19)